Fate of intracellular retained mutant collagen
نویسندگان
چکیده
منابع مشابه
The fate of failed renal homografts retained after retransplantation.
IN MANY TRANSPLANTATION CENTERS, it has been considered obligatory to remove failed renal homografts before, or at, retransplantation, since such grafts have been regarded as a potential hazard to the patient. At our institution, this routine has, in the last years, been applied only to grafts which failed in the immediate postoperative period and which, consequently, were considered infarcted....
متن کاملMutant prion proteins are partially retained in the endoplasmic reticulum.
Familial prion diseases are linked to point and insertional mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP to the infectious isoform. In this report, we have investigated the subcellular localization of PrP molecules carrying pathogenic mutations using immunofluorescence staining, immunogold labeling, and PrP-green fluorescent prot...
متن کاملevaluation of relation between mutant virb2 virulence factor in brucella melitensis with immunogenicity and intracellular survival
objective: the brucella melitensis virb operon, encoding a type iv secretion system (t4ss), is required for intracellular replication and persistent infection in the mouse model. the product of the second gene of the virb operon, virb2, is predicted to be localized at the bacterial surface, where they could potentially interact with host cells. studies to date have focused on characterization o...
متن کاملIntracellular collagen in experimental arthritis in rats.
In recent years the development ofimproved autoradiographic techniques and in particular electron micro-autoradiography (Caro and von Tubergen 1962) has led to a better understanding of collagen fibre production by fibroblasts (Revel and Hay 1963, Ross and Benditt 1965). It is now generally accepted that collagen fibres are formed outside the cell by an extracellular aggregation of soluble coll...
متن کاملThe intracellular fate of a recombinant protein is tissue dependent.
Recombinant proteins directed to the secretory pathway in plants require a signal peptide for entry into the endoplasmic reticulum. In the absence of further targeting information, such proteins are generally secreted via the default pathway to the apoplast. This has been well documented in protoplasts and leaf tissue, but the trafficking of recombinant proteins in seeds and other storage tissu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone Reports
سال: 2020
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2020.100606